Intravenous Lipid Emulsion Does Not Reverse Dabigatran-induced Anticoagulation in a Rat Model
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چکیده
منابع مشابه
Failure of Intravenous Lipid Emulsion to Reduce Diazinon-induced Acute Toxicity: a Pilot Study in Rats
Diazinon (DZN) is a synthetic organophosphorus (OPs) insecticide widely used in agricultural and household applications. OPs, particularly DZN, are highly lipid soluble liquids. Intravenous lipid emulsion (ILE) has been shown to reduce toxicity caused by some lipid soluble agents. We evaluated the antidote effect of ILE on acute toxicity of DZN. Twenty-four Sprague-Dawley female rats weightin...
متن کاملFailure of Intravenous Lipid Emulsion to Reduce Diazinon-induced Acute Toxicity: a Pilot Study in Rats
Diazinon (DZN) is a synthetic organophosphorus (OPs) insecticide widely used in agricultural and household applications. OPs, particularly DZN, are highly lipid soluble liquids. Intravenous lipid emulsion (ILE) has been shown to reduce toxicity caused by some lipid soluble agents. We evaluated the antidote effect of ILE on acute toxicity of DZN. Twenty-four Sprague-Dawley female rats weightin...
متن کاملIntravenous lipid emulsion in clinical toxicology
Intravenous lipid emulsion is an established, effective treatment for local anesthetic-induced cardiovascular collapse. The predominant theory for its mechanism of action is that by creating an expanded, intravascular lipid phase, equilibria are established that drive the offending drug from target tissues into the newly formed 'lipid sink'. Based on this hypothesis, lipid emulsion has been con...
متن کاملfailure of intravenous lipid emulsion to reduce diazinon-induced acute toxicity: a pilot study in rats
diazinon (dzn) is a synthetic organophosphorus (ops) insecticide widely used in agricultural and household applications. ops, particularly dzn, are highly lipid soluble liquids. intravenous lipid emulsion (ile) has been shown to reduce toxicity caused by some lipid soluble agents. we evaluated the antidote effect of ile on acute toxicity of dzn. twenty-four sprague-dawley female rats weighting ...
متن کاملLipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta
We investigated the effect of Lipofundin MCT/LCT and Intralipid on acetylcholine-induced nitric oxide- (NO-) mediated relaxation in rat aorta to determine which lipid emulsion (LE) is more potent in terms of inhibition of NO-induced relaxation. Dose-response curves of responses induced by acetylcholine, the calcium ionophore A23187, and sodium nitroprusside were generated using isolated rat aor...
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ژورنال
عنوان ژورنال: Academic Emergency Medicine
سال: 2013
ISSN: 1069-6563
DOI: 10.1111/acem.12225